Restoration of fertility potential via targeted treatment approach

Restoration of fertility potential via targeted treatment approach

Significance of microRNA targeted estrogen receptor in male fertility

Objective(s): Estrogen receptor-alpha (ERα) mediates estrogen action in regulation of different levels of the hypothalamic-pituitary-testis axis. It has a key role in spermatogenesis. Estrogen receptor alpha knock-out (ER koα) male mice were infertile and severe impairment in spermatogenesis and seminiferous tubules was observed. Recently, it has been reported that microRNA (miRNA) mir-100 and ...

Fertility Preservation and Potential Future Treatment Options

In spite of large improvements in health care technologies and more access to reproductive health services during past decades, there are many reports on human fertility decline .The role of life style and environmental factors on human fertility has attracted more attention recently and is the subject of worldwide studies on causes of male and female factor infertility. The important factors s...

Signal restoration via a splitting approach

In the present study, a novel signal restoration method from noisy data samples is presented and is termed as “signal split (SSplit)” approach. The new method utilizes Stein unbiased risk estimate estimator to split the signal, the Lipschitz exponents to identify noise elements and a heuristic approach for the signal reconstruction. However, unlike many noise removal techniques, the present met...

Inheritance of the fertility restoration and genotyping of rice lines at the restoring fertility (Rf) loci using molecular markers

The combination of cytoplasmic male sterility (CMS) in one parent and a restorer gene (Rf) to restore fertility in another are indispensable for the development of hybrid varieties. To genotype rice lines at the restoring fertility (Rf) loci, 38 lines were crossed with a sterile tester (rfrf) line. Pollen fertility test was performed to identify sterile and fertile F1 hybrids. Seven lines were ...